The transition model of RTK activation: A quantitative framework for understanding RTK signaling and RTK modulator activity
نویسندگان
چکیده
منابع مشابه
RTK/Ras/MAPK signaling.
Receptor Tyrosine Kinase (RTK)/Ras GTPase/MAP kinase (MAPK) signaling pathways are used repeatedly during metazoan development to control many different biological processes. In the nematode Caenorhabditis elegans, two different RTKs (LET-23/EGFR and EGL-15/FGFR) are known to stimulate LET-60/Ras and a MAPK cascade consisting of the kinases LIN-45/Raf, MEK-2/MEK and MPK-1/ERK. This Ras/MAPK cas...
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The dorsoventral (DV) axis of the Drosophila embryo is patterned by a nuclear gradient of the Rel family transcription factor, Dorsal (Dl), that activates or represses numerous target genes in a region-specific manner. Here, we demonstrate that signaling by receptor tyrosine kinases (RTK) reduces nuclear levels and transcriptional activity of Dl, both at the poles and in the mid-body of the emb...
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The RAS/MAP kinase and the RAS/PI3K/AKT pathways play a key role in the regulation of proliferation, differentiation and survival. The induction of these pathways depends on Receptor Tyrosine Kinases (RTKs) that are activated upon ligand binding. In cancer, constitutive and aberrant activations of components of those pathways result in increased proliferation, survival and metastasis. For insta...
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Overactivation of receptor tyrosine kinases (RTKs), caused by either oversupply of ligands or mutations that result in ligandindependent constitutive activation, has been linked to many cancers and other human diseases (reviewed by Robertson et al., 2000). An important question is why such overactivation, which has been generally presumed to be quantitative in nature, could lead to qualitative ...
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During Caenorhabditis elegans vulval development, activation of receptor tyrosine kinase/Ras and Notch signaling pathways causes three vulval precursor cells (VPCs) to adopt induced cell fates. A Wnt signaling pathway also acts in cell fate specification by the VPCs, via regulation of the Hox gene lin-39. We show here that either mutation of pry-1 or expression of an activated BAR-1 beta-cateni...
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ژورنال
عنوان ژورنال: Cytokine & Growth Factor Reviews
سال: 2019
ISSN: 1359-6101
DOI: 10.1016/j.cytogfr.2019.10.004